Triple quadrupole mass spectrometer LCMS-8080

Triple quadrupole mass spectrometer LCMS-8080 LCMS-8080, is designed to achieve high-sensitivity analysis of LC / MS / MS system. With the same grade means leading sensitivity and excellent quantitative. LCMS-8080 triple quadrupole LC / MS / MS system combines with the level of means leading sensitivity and excellent quantitative capability. The key factors in achieving high sensitivity is how to make more efficient ion detector. Ionized interfaces spray jet stream focus, to high efficiency coaxial ionization plus heat, neutral contaminants can be removed and accurately import HSID ion mass spectrometry apparatus, it is possible to transport a large number of high transmittance fast ions to detector laminar flow technology. LCMS-8080 is the collection of the above-mentioned high sensitivity technology. Widely used in pharmaceutical field of product development and manufacturing, clinical research, food or environmental analysis and drug screening, on various occasions have played a remarkable sensitivity. Quantification of trace components in high accuracy can obtain reliable data analysis. Control analysis software with strong support from the quantitative analysis of LabSolutions, providing analysis relaxed work environment. LCMS-8080, is designed to achieve high-sensitivity analysis of LC / MS / MS system. Highly sensitive technology - multi-faceted support sensitivity and durability of technology - superior sensitivity (1) - the same grade means leading sensitivity -?? High temperature heat source of high temperature heating plasma source ion sensitivity enhancement support Plug and Play? ?? ion source to achieve 亚菲克 level detection limits covering a small body in a vertical condensation of a superior high-sensitivity technology superior sensitivity (2) - both highly reliable means to reach the ideal state - easy analysis environment? achieve high accuracy over a wide range of quantitative? automatic MRM optimization? composition excellent stability? and Nexera's? ultra high-sensitivity analysis of cross-contamination can help to achieve accurate quantitation ion high-temperature heat source heating gas from around the coaxial spray a high-temperature gas, improve the efficiency of removal of the solvent. It can be measured with high sensitivity compound ESI wide range of areas. Even at high flow decreased sensitivity can be suppressed to achieve stability analysis in high traffic areas maximum feed liquid flow rate 3 mL / min of. HSID [Hot Source Induced Desolvation] multi rectangular heated interface design, import more ions while removing noise components, reducing chemical noise. Excess spray from the rapid exhaust system, improves the device life. No need to replace the ion source, may correspond to a wide range of samples. Plug and Play Plug ion source can land setting means, without the cumbersome operation. Cable-free design, without the need for cable connections to operate. Gas pipe for voltage cable completely ruled outside the scope of the maintenance, maintenance operations can without touching the gas pipes, cables. Means to facilitate the demolition, saving maintenance time. Small footprint vertical condensation of the fuselage of a superior high-sensitivity technology LCMS-8080 uses a small footprint vertical body, the unparalleled high sensitivity technology housed in a 50cm × 50cm only to a small space. Using a unique coaxial plus heat and HSID technology to achieve the leading level of sensitivity. Significantly lower detection limit. LCMS-8080 stood peak sensitivity, extensive correspondence of all the target sample, providing high sensitivity information. High-temperature heat sensitivity ion source to support the use of proprietary technology to enhance the high-temperature heating ion source, plus coaxial heat helps ionized. As shown on the left, coaxial heat plus the signal strength increased by 8 times. Because coaxial plus heat of action, can be measured with high sensitivity ESI source sample from a high polarity to the polarity of the low use of a wide range of polarities. HSID of refraction portion, the contact area with the high temperature heating portion of the ion increases. Improve the efficiency of removal of the solvent, will reduce chemical noise to the limit, to contribute to enhance the signal strength. So that the LCMS-8080 to maximize the signal, for various types of compounds to achieve 亚飞克 Ake level detection limits. Bulky differential exhaust system can import a large number of ions, use Triple RF ion guides laminar flow, inhibit ion diffusion, high-sensitivity analysis can be performed. Achieve 亚飞克 level test line to the left of data 0.5 pg / mL of verapamil MRM chromatograms.亚飞克 area near the limit of detection to obtain excellent sensitivity. Column: Shim-pack XR-ODSⅢ 2.0 mmI.D. × 50 mmL, 1.6 μm Mobile phase:. 5 mmol / L ammonium acetate - water / acetonitrile = 10/90 flow rate: 0.5 mL / min right of the data for the 5 pg / mL pharmaceuticals three components MRM chromatogram. Area values ??of all components of reproducibility RSD <6%, low noise levels and excellent selectivity, so quantitation limit of the number of fly grams. Left side data is an important substance testosterone steroids MRM chromatograms. Less polar steroids, ESI ionization method is difficult, it is generally measured using APCI method. However, for a wide range of ESI LCMS-8080 law, even steroids such polar analytes to be the same sample with high polarity, high-sensitivity analysis. Area near the limit of quantitation values ??2pg / mL, 6 replicate analyzes of reproducibility RSD was 4.34%, high sensitivity, high accuracy detection. Column: Shim-pack XR-ODSⅢ 2.0 mmI.D. × 50 mmL, 1.6 μm Mobile Phase A:. 0.1% formic acid - water mobile phase B: acetonitrile Flow rate: 0.4 mL / min LCMS - 8 0 8 0 for a wide range of Samples with a high level of sensitivity and reliability. Even in the past that minim quantitative analysis impossible, but also provide reliable information. Strongly support the analysis of a specific component testing, quality management and all occasions. LCMS-8080 to achieve high accuracy quantitative possess high sensitivity over a wide range of quantitative extended to low-concentration region. From a low concentration to high concentration in a wide concentration range exhibits excellent linearity to achieve a quantitative analysis of a wide range of concentrations. Hiro cilostazol work curve from 2pg / mL to 50ng / mL of the dynamic range was R2 = 0.9999 this excellent linearity. Even at low concentrations, but also to achieve the relative error of 10% or less, and area values ??reproducible results below 15%. Thus, from a low concentration to a high concentration of a wide range of highly accurate analysis can be performed. As described above, LCMS-8080 combines superior sensitivity and quantitative. Excellent stability LCMS-8080 uses a small sample in the ion source of residual exhaust system and HSID fast multi-refraction and high-temperature heating system at all times maintained in a clean condition. Even in the impurity component content of sample analysis, also play outstanding durability, continue to provide reliable data. For added atorvastatin plasma samples, the pretreatment methods were described by the left side of the protein was removed using the LCMS-8080 carried out 700 consecutive analysis. The following figure shows an area 700 times change and 1,300,700 times the value of the results of MRM chromatograms result of continuous analysis. Peak area reproducibility of 2.11% RSD, proved the high durability and excellent LCMS-8080 peak area reproducibility. LabSolutions LCMS Ver.5 is an integrated workstation software, you can control the LCMS-2020/8030/8040 systems also include LC-VP, Prominence series Nexera UHPLC and HPLC series of comprehensive control. Standard data processing include quantitative browser, providing a convenient quantitative capabilities for multiple analytes. Its data browser allows the operator to easily analyze and compare multiple sets of data or spectra in the same window. The workstation may be LC and MS data link, which is particularly important to find or determine compound. In addition, the popular report function is extended to the results can be printed in different formats. Lab Solutions LCMS Ver.5.5 automatically optimize MRM MRM condition optimization is an important step when using a triple quadrupole mass spectrometer making quantitative methods indispensable. LCMS-8080 MRM parameters using an automatic system optimization flow injection analysis. LabSolutions software includes optimization features that anyone can easily implement parameter optimization. / Ideal combination Nexera combination LCMS-8080 and SIL-30AC SIL-30ACMP and, at the same time achieve a multi-sample analysis and low cross-contamination. Accelerate the analysis the total flux. Ultra-low cross-contamination contribute to the high sensitivity analysis, accurate quantitation front end LC MS meet the requirements to reduce cross-contamination, in the analysis of easily adsorbed compounds also achieved a low cross-contamination. With up to 4 multi-cleaning fluid, in all cases we have achieved a very low cross-contamination. Data in the left, and the injection 10μg / mL reserpine, the peak intensity and then into the blank after concentration in terms of 26 pg / mL. That even in very high concentrations into the sample after cross-contamination is still being controlled at 0.00023 percent this low value.