Science newfound reversal of female infertility

 Kelli reported the researchers found that during meiosis, a protein responsible for marking eggs with damaged DNA, and start the process of removing a bad egg female body. The study published in the January 31 "Science" (Science) magazine. The protein known as Chk2 unrepaired chromosomal breaks for culling of mouse oocytes with play a vital role. Such damage may occur during meiosis or caused by the radiation. Role of this protein in a time-sensitive, if you can not be fixed at a certain time frame DNA damage, these eggs will be killed. The researchers fed some Trip13 carry a gene mutation in mice, this variation contributes to the process of meiosis egg and sperm cells failure. When they Chk2 gene silencing in these mice, the researchers reversed the infertile female mice. By closing this unrepaired DNA identification system, researchers think they may be able to gain time to repair the egg. The researchers said, "In the laboratory, all oocytes from rescue offspring were normal.": "There are some defective genes responsible for the killing of oocytes, but we still do not know which genes we want to. determine the genetic quality of control mechanisms. "cell, ie sperm and egg are forms of cell division through meiosis to produce this. During meiosis, the chromosomes from parents to exchange part of DNA. Such restructuring requires the chromosomal DNA double-strand breaks occur, thereby generating new combinations of genes in male and female, to improve the genetic variation. Restructuring or reorganization missing error may cause miscarriage or class of diseases such as Down syndrome. In still a fetus, most mammals generates the required life of all female oocytes. The immature oocyte pool stored for later use in the ovary. But when exposed to radiation, and those immature eggs are particularly vulnerable to DNA damage. In the ovulation process during the growing period, some of the egg after meiosis stage. At this stage, Chk2 protein ensures that the egg will not damage DNA errors passed to the next generation. By silencing Chk2 gene, the researchers for the cells to repair DNA damage to win more time to generate some dynamic eggs, restore fertility. In this study, the researchers destroyed the Chk2 gene that causes no Chk2 protein production. Now, researchers are working to adopt a number of known drugs to inhibit Chk2 protein, which may be applied to some of the treatment to prevent the emergence of women receiving anti-cancer therapy infertility. The next step of this research is to understand the technology only for eggs with sperm DNA damage without contributing causes. The researchers believe that sex differences between men chromosome (XY) and female (XX) between meiosis and different time men are likely to play a role. Articles are selected from: http: //0991-8781769.com/yygk/kycj/19787.html reproduced, please indicate the source